Endocrine Abstracts

A range of hormones which regulate energy metabolism are secreted by adipose tissue, among which adiponectin and leptin are the main adipokines regulating insulin sensitivity.The aim of our study was to estimate and compare levels of adiponectin, leptin, C-peptide and adiponectin-to-leptin ratio (A/L) in obese non-diabetic, Type 1 diabetic (T1D) children and lean non-diabetic controls.BMI and SDS BMI were calculated in 88 children ...

The aim: To test cytotoxic effects of immune factors of patients with chronic diabetic foot ulcers on keratinocytes and fibroblasts in a 3D skin culture system.Materials and methods: In this study a multilayer 3D human skin model comprising of keratinocytes, fibroblasts and dendritic cells in an agarose-fibronectin gel was used. 20% serum of 13 patients with chronic noninfected diabetic foot ulcers, 13 diabetic type 2 patients and 13 healthy people and l...

Objective: A diabetic state is causally related to heart failure (HF) which is a leading cause of mortality. Early detection of high-risk individuals is imperative for primary prevention. The aim of this study was to investigate the role of N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) in patients with diabetes type 2 (DT2).Methods: We investigated 86 patients both sexes with DT2 aged 65.54±11.37 years (from 50 to 65 years) without clinical ...

Purpose: Estimation of the continuous glucose monitoring system (CGMS) in the value of diabetes mellitus type 1 (DM1) control.Materials and methods: 162 DM1 patients have been divided on 2 groups: 1st group with adequate control DM1 – glycated hemoglobin (HbA1C) ≤7.5% (n=38) and 2nd group with inadequate control – HbA1C>7.5% (n=124). All patients carried out CGMS with glycemia symmetrization scales and an estimation ...

Neutrophil gelatinase-associated lipocalin (NGAL) was shown to be highly useful in assessing kidney injury in patients with diabetic nephropathy. Taking into account recent data that dysthyroidism may have reversible effects on GFR the purpose of the study was to investigate potential relationship between serum NGAL levels, thyroid status and ultrasound thyroid characteristics in patients with type 1 diabetes (T1D) with CKD.Materials and methods: We recr...

Purpose: Estimation of the continuous glucose monitoring system (CGMS) in the value of diabetes mellitus type 1 (DM1) control.Materials and methods: 162 DM1 patients have been divided on 2 groups: 1st group with adequate control DM1 – glycated hemoglobin (HbA1C) ≤7.5% (n=38) and 2nd group with inadequate control – HbA1C>7.5% (n=124). All patients carried out CGMS with glycemia symmetrization scales and an estimation ...

Neutrophil gelatinase-associated lipocalin (NGAL) was shown to be highly useful in assessing kidney injury in patients with diabetic nephropathy. Taking into account recent data that dysthyroidism may have reversible effects on GFR the purpose of the study was to investigate potential relationship between serum NGAL levels, thyroid status and ultrasound thyroid characteristics in patients with type 1 diabetes (T1D) with CKD.Materials and methods: We recr...

Objective: To determine the effects of hypoglycemia while sleeping on somnological parameters for patients with type 1 DM.Materials and methods: The study included 57 person with type 1 DM (Group 1 – patients with blood glucose levels (BGL) during sleep <3.9 mmol/l; Group 2 – Patients with BGL – from 3.9 to 10.0 mmol/l. The examination included: daily monitoring of blood glucose by ‘CGMSGold’ (‘MedtronikMINIMED’ (US...

It is determined that sleep apnea itself can affect the level of HbA1c, thereby affecting the compensation of carbohydrate metabolism in type 2 diabetes.Objective: To determine the quantity and type of sleep apnea in diabetes type 1, depending on the level of HbA1c.Materials and methods: The study involved 50 people with type 1 diabetes without the presence of diabetic autonomic neuropathy or diseases of the pulmonary system and EN...

Background: Diabetic nephropathy (DN) is a major cause of morbidity and mortality in type 1 diabetes (T1D) patients and associated with increased cardiovascular risk in type 2 diabetes (T2D) patients. Early detection of DN using neutrophil gelatinase-associated lipocalin (NGAL) assessment can help to reveal predisposed patients to its progression and to prevent progression of DN. Especially important it is in patients with normoalbuminuria.Aim: To determ...